The dancer is a nurse with purple hair. She wears a pink nurse jacket over a purple dress, a pink nurse's hat, and pink stilettos. Her jacket has two purple pockets that have white-on-pink medical crosses on them and her hat has a cross. She also has a pink stethoscope in her ears and a purple bracelet on her left arm. During the chorus, her outfit and hair change from pink to black, but the crosses on her outfit remain visible. In Just Dance Wii, she simply darkens instead. During the bridge, she flashes dark pink then briefly turns pitch black.
In the remake, the dancer has a lighter and more realistic color scheme and has a pink outline.
The routine takes place in what is supposed to be a pink nuclear central room, with a purple radiation sign, other purple signs, and many lights including pink smoke coming out from the bottom. During the chorus, it turns into a dark red room with horizontal neon lines whose back and sides flash with red stripes and the pink smoke becomes red.
Toxic background - Just Dance Greatest Hits - Best Of
On the menu icons in Just Dance 2 and Just Dance Wii, the coach is missing her glove and in place of it is her bracelet which is supposed to be on her other arm.
In the Japanese version, the hazard sign is replaced with a caution sign and the placement of motions of the doors that open are rearranged, like in the Beta version of the European routine.
On the menu icons in Just Dance 2, Just Dance 3, Just Dance: Greatest Hits/Best Of, the big hazard sign has two smaller hazard signs inside of it, even though they are not present in-game. This is also the case with the warning sign in Just Dance Wii.
Originally in the chorus, the coach became darkened instead of black.
This Beta element was later used in the Just Dance Wii version.
In the Just Dance Wii version, the coach becomes un-darkened during the final chorus.
In Good Feeling’s Mashup, fewer moves are counted for during this dancer's sequence than in the actual routine; it is at the part where she pushes her arms to the left and raises her right leg.
In the 20150325_1222 version of the Just Dance Now files, Toxic’s files were no longer accessible. However, later in the 20150422_1529 version, Toxic was re-added to the files with a different icon and different pictograms.